SOX9 induces and maintains neural stem cells
Copyright policy )SOX9 induces and maintains neural stem cells
Neural stem cells (NSCs) are uncommitted cells of the CNS defined by their multipotentiality and ability to self renew. We found these cells to not be present in substantial numbers in the CNS until after embryonic day (E) 10.5 in mouse and E5 in chick. This coincides with the induction of SOX9 in neural cells. Gain- and loss-of-function studies indicated that SOX9 was essential for multipotent NSC formation. Moreover, Sonic Hedgehog was able to stimulate precocious generation of NSCs by inducing Sox9 expression. SOX9 was also necessary for the maintenance of multipotent NSCs, as shown by in vivo fate mapping experiments in the adult subependymal zone and olfactory bulbs. In addition, loss of SOX9 led ependymal cells to adopt a neuroblast identity. These data identify a functional link between extrinsic and intrinsic mechanisms of NSCs specification and maintenance, and establish a central role for SOX9 in the process.
- University of Hong Kong (香港大å¸) China (People's Republic of)
- National Institute for Medical Research United Kingdom
- National Institute for Medical Research Tanzania (United Republic of)
- University of Hong Kong China (People's Republic of)
- Medical Research Council United Kingdom
571, Green Fluorescent Proteins, Cell Count, Mice, Transgenic, Nerve Tissue Proteins, Neural Cell Adhesion Molecule L1, In Vitro Techniques, Gene Expression Regulation, Enzymologic, Mice, Enzymologic - genetics, Cell Differentiation - genetics, Animals, Cells, Cultured, SOX9 Transcription Factor - genetics - metabolism, Oligonucleotide Array Sequence Analysis, Neurons, Gene Expression Profiling, SOXB1 Transcription Factors, Gene Transfer Techniques, Cell Differentiation, SOX9 Transcription Factor, Embryo, Mammalian, Gene Expression Regulation, Enzymologic - genetics, Gene Expression Regulation, Bromodeoxyuridine, Stem Cells - physiology, Neurons - physiology, Chickens
571, Green Fluorescent Proteins, Cell Count, Mice, Transgenic, Nerve Tissue Proteins, Neural Cell Adhesion Molecule L1, In Vitro Techniques, Gene Expression Regulation, Enzymologic, Mice, Enzymologic - genetics, Cell Differentiation - genetics, Animals, Cells, Cultured, SOX9 Transcription Factor - genetics - metabolism, Oligonucleotide Array Sequence Analysis, Neurons, Gene Expression Profiling, SOXB1 Transcription Factors, Gene Transfer Techniques, Cell Differentiation, SOX9 Transcription Factor, Embryo, Mammalian, Gene Expression Regulation, Enzymologic - genetics, Gene Expression Regulation, Bromodeoxyuridine, Stem Cells - physiology, Neurons - physiology, Chickens
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