Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
Copyright policy )AKA| The biological role of Helios transcription factor in the human immune system.
Iivo Hetemäki; Meri Kaustio; Matias Kinnunen; Nelli Heikkilä; Salla Keskitalo; Kirsten Nowlan; Simo Miettinen; +19 Authors
Iivo Hetemäki; Meri Kaustio; Matias Kinnunen; Nelli Heikkilä; Salla Keskitalo; Kirsten Nowlan; Simo Miettinen; Joona Sarkkinen; Virpi Glumoff; Noora Andersson; Kaisa Kettunen; Reetta Vanhanen; Katariina Nurmi; Kari K. Eklund; Johannes Dunkel; Mikko I. Mäyränpää; Heinrich Schlums; T. Petteri Arstila; Kai Kisand; Yenan T. Bryceson; Pärt Peterson; Ulla Otava; Jaana Syrjänen; Janna Saarela; Markku Varjosalo; Eliisa Kekäläinen;
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
A truncated variant of Helios causes a human immunodeficiency disease with signs of immune overactivation.
Finland
- Karolinska Institute Sweden
- Oulu University Hospital Finland
- Oslo University Hospital Norway
- Helsinki University Hospital Finland
- Institute for Molecular Medicine Finland Finland
Adult, Male, Middle Aged, Germinal Center, Mucosal-Associated Invariant T Cells, Biomedicine, Ikaros Transcription Factor, Young Adult, Genetics, developmental biology, physiology, Humans, Female, Aged
Adult, Male, Middle Aged, Germinal Center, Mucosal-Associated Invariant T Cells, Biomedicine, Ikaros Transcription Factor, Young Adult, Genetics, developmental biology, physiology, Humans, Female, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).56 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 56
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