miR-144 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting E2F3
Copyright policy )miR-144 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting E2F3
MicroRNAs (miRNAs) play essential roles in the progression of hepatocellular carcinoma (HCC). miR-144 acts as a tumor suppressor in some malignancies, while its role in HCC is unclear. Here, we found that miR-144 was significantly decreased in HCC tissues and cell lines. Forced overexpression of miR-144 remarkably reduced cell proliferation, increased apoptosis, and suppressed migration and invasion of HCC cells. E2F transcription factor 3 (E2F3) was identified as a target of miR-144 in HCC cells. Moreover, E2F3 overexpression partially attenuated the tumor suppressive effects of miR-144, and the expression of E2F3 was negatively correlated with miR-144 level in HCC tissues. Our data suggest that miR-144 might suppress the growth and motility of HCC cells partially by targeting E2F3.
- General Hospital of Central Theater Command China (People's Republic of)
Carcinoma, Hepatocellular, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Liver Neoplasms, Apoptosis, Flow Cytometry, Real-Time Polymerase Chain Reaction, Gene Expression Regulation, Neoplastic, MicroRNAs, Liver, Cell Movement, E2F3 Transcription Factor, Tumor Cells, Cultured, Humans, RNA, Messenger, Cell Proliferation
Carcinoma, Hepatocellular, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Liver Neoplasms, Apoptosis, Flow Cytometry, Real-Time Polymerase Chain Reaction, Gene Expression Regulation, Neoplastic, MicroRNAs, Liver, Cell Movement, E2F3 Transcription Factor, Tumor Cells, Cultured, Humans, RNA, Messenger, Cell Proliferation
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