IGF2R Missense Single-Nucleotide Polymorphisms and Breast Cancer Risk: The Multiethnic Cohort Study
Copyright policy )IGF2R Missense Single-Nucleotide Polymorphisms and Breast Cancer Risk: The Multiethnic Cohort Study
Abstract IGF2R has been proposed to be a tumor suppressor gene given its antagonist role on cellular growth and evidence of loss of heterozygosity in several cancers, including breast cancer. To investigate whether inherited differences in potentially functional IGF2R variants influence the risk of breast cancer, we sequenced 46 exons of IGF2R to identify novel missense single-nucleotide polymorphisms (SNP) and tested 12 missense SNPs for their associations with breast cancer risk among 1,614 breast cancer cases and 1,960 controls from the Multiethnic Cohort. None of these missense SNPs were significantly associated with breast cancer risk. Our findings provide no evidence that missense SNPs in IGF2R influence breast cancer susceptibility.(Cancer Epidemiol Biomarkers Prev 2009;18(6):1922–4)
- University of Hawaii System United States
- University of Hawaiʻi Sea Grant United States
- University of California System United States
- USC Norris Cancer Hospital United States
- Keck Hospital of USC United States
Genotype, Mutation, Missense, Breast Neoplasms, Middle Aged, Polymorphism, Single Nucleotide, Receptor, IGF Type 2, Cohort Studies, Case-Control Studies, Ethnicity, Humans, Female, Genetic Predisposition to Disease, Aged
Genotype, Mutation, Missense, Breast Neoplasms, Middle Aged, Polymorphism, Single Nucleotide, Receptor, IGF Type 2, Cohort Studies, Case-Control Studies, Ethnicity, Humans, Female, Genetic Predisposition to Disease, Aged
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