Genetic Association of GABA‐A Receptor Alpha‐2 and Mu Opioid Receptor with Cocaine Cue‐Reactivity: Evidence for Inhibitory Synaptic Neurotransmission Involvement in Cocaine Dependence
Copyright policy )Genetic Association of GABA‐A Receptor Alpha‐2 and Mu Opioid Receptor with Cocaine Cue‐Reactivity: Evidence for Inhibitory Synaptic Neurotransmission Involvement in Cocaine Dependence
Background:This pilot feasibility study examined the role of genetics in laboratory‐induced cocaine craving.Methods:Thirty‐four African American, cocaine‐depend‐ ent male subjects underwent a baseline assessment, cue‐exposure session, and genetic analysis. Subjects were classified as either cue‐reactive or nonreactive.Results:Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue‐reactivity, two were statistically significant: GABRA2 (coding for GABA‐A receptor alpha‐2 subunit; rs11503014, nominalp= .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominalp= .03).Conclusions:These pilot results suggest that cocaine craving shows variability among cocaine‐dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue‐reactivity, warranting studies in future research. (Am J Addict 2012;21:411–415)
- Veterans Health Administration United States
- University of Massachusetts Medical School United States
- Rutgers, The State University of New Jersey United States
Adult, Male, Genotype, Receptors, Opioid, mu, Psychiatry and Psychology, Opioid, Substance Abuse and Addiction, Polymorphism, Single Nucleotide, Synaptic Transmission, Cocaine-Related Disorders, Receptors, Humans, African Americans, Psychiatry, Neuroscience and Neurobiology, GABA-A, Genetics and Genomics, Single Nucleotide, Receptors, GABA-A, Black or African American, Logistic Models, mu, Feasibility Studies, Cues, *Polymorphism
Adult, Male, Genotype, Receptors, Opioid, mu, Psychiatry and Psychology, Opioid, Substance Abuse and Addiction, Polymorphism, Single Nucleotide, Synaptic Transmission, Cocaine-Related Disorders, Receptors, Humans, African Americans, Psychiatry, Neuroscience and Neurobiology, GABA-A, Genetics and Genomics, Single Nucleotide, Receptors, GABA-A, Black or African American, Logistic Models, mu, Feasibility Studies, Cues, *Polymorphism
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