Relnrl-Alb2,an Allele ofReelerIsolated from a Chlorambucil Screen, Is Due to an IAP Insertion with Exon Skipping
Copyright policy )Relnrl-Alb2,an Allele ofReelerIsolated from a Chlorambucil Screen, Is Due to an IAP Insertion with Exon Skipping
The reeler Albany2 mutation (Reln(rl-Alb2) in the mouse is an allele of reeler isolated during a chlorambucil mutagenesis screen. Homozygous animals had drastically reduced concentrations of reelin mRNA, in which an 85-nt exon was absent. At the genomic level, the mutation was shown to be due to an intracisternal A-particle insertion leading to exon skipping. This appears to be the first observation of retrotransposon insertion during chlorambucil mutagenesis.
- New York State Department of Health United States
- Wadsworth Center United States
Male, Extracellular Matrix Proteins, Mice, Inbred C3H, Base Sequence, Cell Adhesion Molecules, Neuronal, Homozygote, Molecular Sequence Data, Serine Endopeptidases, Nerve Tissue Proteins, Exons, Mice, Mutagenesis, Insertional, Reelin Protein, Genes, Intracisternal A-Particle, Animals, Chlorambucil, Female, RNA, Messenger, Alleles
Male, Extracellular Matrix Proteins, Mice, Inbred C3H, Base Sequence, Cell Adhesion Molecules, Neuronal, Homozygote, Molecular Sequence Data, Serine Endopeptidases, Nerve Tissue Proteins, Exons, Mice, Mutagenesis, Insertional, Reelin Protein, Genes, Intracisternal A-Particle, Animals, Chlorambucil, Female, RNA, Messenger, Alleles
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