Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice
Copyright policy )Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice
Recently identified chondroitin sulphate proteoglycans in perineuronal nets include neurocan and phosphacan. However, the function and assembly of these components has yet to be resolved. In this study we show morphological alteration in Wisteria floribunda labelled nets around cortical interneurones both in tenascin-R knockout and tenascin-R/parvalbumin double knockout mice. This alteration reflects the loss of phosphacan and neurocan from cortical nets in mice deficient in tenascin-R. No effect on the membrane related cytoskeleton, as revealed by ankyrin(R), was observed in any of the mice. These results on mice lacking tenascin-R substantiate previously reported in vitro interactions between tenascin-R and phosphacan and neurocan.
- Universität Hamburg Germany
- University of Fribourg Switzerland
Cerebral Cortex, Mice, Knockout, Neurons, Receptor-Like Protein Tyrosine Phosphatases, Class 5, Fluorescent Antibody Technique, Nerve Tissue Proteins, Tenascin, Extracellular Matrix, Mice, Parvalbumins, Chondroitin Sulfate Proteoglycans, Animals, Lectins, C-Type, Neurocan, Cell Size
Cerebral Cortex, Mice, Knockout, Neurons, Receptor-Like Protein Tyrosine Phosphatases, Class 5, Fluorescent Antibody Technique, Nerve Tissue Proteins, Tenascin, Extracellular Matrix, Mice, Parvalbumins, Chondroitin Sulfate Proteoglycans, Animals, Lectins, C-Type, Neurocan, Cell Size
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).43 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!