IFNγ Helps CBLB-Deficient CD8+ T Cells to Put Up Resistance to Tregs

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Apr 2022 English Publisher:American Association for Cancer Research (AACR)Journal:Cancer Immunology Research, volume 10, pages 370-370 (issn: 2326-6066, eissn: 2326-6074,

Authors: Dominik, Wolf; Gottfried, Baier;

doi: 10.1158/2326-6066.cir-22-0080

pmid: 35362047

IFNγ Helps CBLB-Deficient CD8+ T Cells to Put Up Resistance to Tregs

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Abstract

Abstract In this issue, Han and colleagues demonstrate in preclinical cancer models that genetic deletion of the E3 ubiquitin ligase Cbl proto-oncogene B (CBLB) in adoptively transferred CD8+ T cells induces resistance to regulatory T cells. CBLB deletion induces IFNγ and downmodulates TGFβ/SMAD signaling. This ultimately enforces these cells to be way more effective against various cancers. See related article by Han et al., p. 437 (4).

Related Organizations

Innsbruck Medical University
Austria

Keywords

Interferon-gamma, Ubiquitin-Protein Ligases, Proto-Oncogene Proteins c-cbl, CD8-Positive T-Lymphocytes, Adaptor Proteins, Signal Transducing

8 Research products, page 1 of 1

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