MOESM1 of Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein

descriptionPublicationkeyboard_double_arrow_right Other literature type 01 Jan 2019Publisher:figshare

Authors: Moszczynski, Alexander; Harvey, Madeline; Niveen Fulcher; Cleusa Oliveira; McCunn, Patrick; Donison, Neil; Bartha, Robert; +3 Authors

doi: 10.6084/m9.figshare.10278299.v1 , 10.6084/m9.figshare.10278299

MOESM1 of Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein

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Abstract

Additional file 1: Figure S1. Schematic depicting the rat model used in the TDP-43M337V experiments. A) Cartoon representation of background (Sprague-Dawley) line used to generate ChAT-tTA (Choline acetyltransferase promoter paired with tetracycline transactivator promoter) and TRE-TDP-43M337V (tetracycline response element paired with mutant human TDP-43M337V) non-expressor lines. Crossing these two lines generates the ChAT-tTA/TRE-TDP-43M337V animals used in experiments. B) Cartoon representation of TDP-43M337V suppression by tTA in the presence of doxycycline (DOX) and expression in the absence of doxycyline.

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