Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB
Copyright policy )Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB
Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in which different genetic and environmental susceptibility factors are involved. Several lines of evidence support the view that at least 30% of ADHD patients diagnosed in childhood continue to suffer the disorder during adulthood and that genetic risk factors may play an essential role in the persistence of the disorder throughout lifespan. Genetic, biochemical and pharmacological studies support the idea that the serotonin system participates in the etiology of ADHD. Based on these data, we aimed to analyze single nucleotide polymorphisms across 19 genes involved in the serotoninergic neurotransmission in a clinical sample of 451 ADHD patients (188 adults and 263 children) and 400 controls using a population-based association study. Several significant associations were found after correcting for multiple testing: (1) the DDC gene was strongly associated with both adulthood (P=0.00053; odds ratio (OR)=2.17) and childhood ADHD (P=0.0017; OR=1.90); (2) the MAOB gene was found specifically associated in the adult ADHD sample (P=0.0029; OR=1.90) and (3) the 5HT2A gene showed evidence of association only with the combined ADHD subtype both in adults (P=0.0036; OR=1.63) and children (P=0.0084; OR=1.49). Our data support the contribution of the serotoninergic system in the genetic predisposition to ADHD, identifying common childhood and adulthood ADHD susceptibility factors, associations that are specific to ADHD subtypes and one variant potentially involved in the continuity of the disorder throughout lifespan.
Adult, Male, Serotonin, Other subheadings::Other subheadings::Other subheadings::/genetics, Adolescent, Genotype, DNA Mutational Analysis, FENÓMENOS Y PROCESOS::fenómenos genéticos::genotipo::predisposición genética a la enfermedad, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Young Adult, Serotonina - Receptors, Gene Frequency, Otros calificadores::Otros calificadores::Otros calificadores::/genética, Odds Ratio, Trastorn per dèficit d'atenció amb hiperactivitat - Aspectes genètics, Humans, Genetic Predisposition to Disease, Receptor, Serotonin, 5-HT2A, Child, Monoamine Oxidase, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad, PHENOMENA AND PROCESSES::Genetic Phenomena::Genotype::Genetic Predisposition to Disease, Middle Aged, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity, COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas::receptores de superficie celular::receptores de aminas biógenas::receptores de serotonina, Attention Deficit Disorder with Hyperactivity, CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Biogenic Amine::Receptors, Serotonin, Dopa Decarboxylase, Female
Adult, Male, Serotonin, Other subheadings::Other subheadings::Other subheadings::/genetics, Adolescent, Genotype, DNA Mutational Analysis, FENÓMENOS Y PROCESOS::fenómenos genéticos::genotipo::predisposición genética a la enfermedad, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Young Adult, Serotonina - Receptors, Gene Frequency, Otros calificadores::Otros calificadores::Otros calificadores::/genética, Odds Ratio, Trastorn per dèficit d'atenció amb hiperactivitat - Aspectes genètics, Humans, Genetic Predisposition to Disease, Receptor, Serotonin, 5-HT2A, Child, Monoamine Oxidase, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad, PHENOMENA AND PROCESSES::Genetic Phenomena::Genotype::Genetic Predisposition to Disease, Middle Aged, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity, COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas::receptores de superficie celular::receptores de aminas biógenas::receptores de serotonina, Attention Deficit Disorder with Hyperactivity, CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Biogenic Amine::Receptors, Serotonin, Dopa Decarboxylase, Female
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