PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3
Copyright policy )PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3
Significance Prostate cancer has an unpredictable natural history: While most tumors are clinically indolent, some patients display lethal phenotypes. Serum prostate-specific antigen is the most often used test in prostate cancer but screening is controversial. Treatment options are limited for metastatic disease, hence the need for early diagnosis. Prostate cancer antigen 3 ( PCA3 ), a long noncoding RNA, is the most specific biomarker identified and approved as a diagnostic test. However, its inherent biological function (if any) has remained elusive. We uncovered a negative transdominant oncogenic role for PCA3 that down-regulates an unrecognized tumor suppressor gene, PRUNE2 (a human homolog of the Drosophila prune gene) thereby promoting malignant cell growth. This work defines a unique biological function for PCA3 in prostate cancer.
- University of Alaska Fairbanks United States
- AC Camargo Hospital Brazil
- UNM Comprehensive Cancer Center United States
- University of California, San Francisco United States
- University of California, San Diego United States
Male, Aging, Adenosine Deaminase, Mice, SCID, Mice, RNA Precursors, 2.1 Biological and endogenous factors, Aetiology, Cancer, Tumor, Reverse Transcriptase Polymerase Chain Reaction, Prostate Cancer, prostate cancer, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, PRUNE2, MCF-7 Cells, Long Noncoding, PCA3, RNA Interference, RNA, Long Noncoding, Biotechnology, Protein Binding, Urologic Diseases, Immunoblotting, Molecular Sequence Data, SCID, Cell Line, Antigens, Neoplasm, Cell Line, Tumor, Genetics, Animals, Humans, long noncoding RNA, Antigens, Neoplastic, Tumor Suppressor Proteins, Prostatic Neoplasms, Xenograft Model Antitumor Assays, ADAR, Introns, HEK293 Cells, Gene Expression Regulation, Hela Cells, ADAR; Long noncoding RNA; PCA3; Prostate cancer; PRUNE2; Multidisciplinary, Neoplasm, RNA, HeLa Cells
Male, Aging, Adenosine Deaminase, Mice, SCID, Mice, RNA Precursors, 2.1 Biological and endogenous factors, Aetiology, Cancer, Tumor, Reverse Transcriptase Polymerase Chain Reaction, Prostate Cancer, prostate cancer, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, PRUNE2, MCF-7 Cells, Long Noncoding, PCA3, RNA Interference, RNA, Long Noncoding, Biotechnology, Protein Binding, Urologic Diseases, Immunoblotting, Molecular Sequence Data, SCID, Cell Line, Antigens, Neoplasm, Cell Line, Tumor, Genetics, Animals, Humans, long noncoding RNA, Antigens, Neoplastic, Tumor Suppressor Proteins, Prostatic Neoplasms, Xenograft Model Antitumor Assays, ADAR, Introns, HEK293 Cells, Gene Expression Regulation, Hela Cells, ADAR; Long noncoding RNA; PCA3; Prostate cancer; PRUNE2; Multidisciplinary, Neoplasm, RNA, HeLa Cells
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