small bristles Is Required for the Morphogenesis of Multiple Tissues During Drosophila Development
Copyright policy )small bristles Is Required for the Morphogenesis of Multiple Tissues During Drosophila Development
Abstract We found that mutations in small bristles (sbr) affect several tissues during the development of the fruit fly. In sbr embryos, neurons have defects in pathfinding and the body wall muscles have defective morphology. As adults, sbr flies have smaller and thinner bristles with a reduced diameter, suggesting a defective cytoskeleton within. The phenotypes we observe are consistent with defects in cell morphogenesis. We identified DmNXF1, the Drosophila homolog of a mRNA export protein that has been characterized in human (NXF1/TAP) and yeast (Mex67p) as the protein encoded by the small bristles locus. Given that a global decrease in mRNA export in these mutants is likely, the phenotypes we observe suggest that certain tissues are acutely sensitive to lower levels of cytoplasmic mRNA and the resultant decrease in protein synthesis during key stages of cellular morphogenesis.
- UNIVERSITY OF EDINBURGH
- Wellcome Trust United Kingdom
- University of Edinburgh
- Harvard Medical School United States
- Universtity of Edinburgh United Kingdom
Cytoplasm, Base Sequence, Models, Genetic, Muscles, Molecular Sequence Data, Chromosome Mapping, Nuclear Proteins, Protein Structure, Tertiary, Phenotype, Mutation, Microscopy, Electron, Scanning, Animals, Drosophila Proteins, Cell Lineage, Drosophila, Amino Acid Sequence, Cloning, Molecular, Alleles, Polymorphism, Restriction Fragment Length, DNA Damage
Cytoplasm, Base Sequence, Models, Genetic, Muscles, Molecular Sequence Data, Chromosome Mapping, Nuclear Proteins, Protein Structure, Tertiary, Phenotype, Mutation, Microscopy, Electron, Scanning, Animals, Drosophila Proteins, Cell Lineage, Drosophila, Amino Acid Sequence, Cloning, Molecular, Alleles, Polymorphism, Restriction Fragment Length, DNA Damage
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