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Four novel genes associated with longevity found in Cane Corso purebred dogs

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 25 Feb 2022Publisher:Research Square Platform LLCJournal:BMC Veterinary Research, volume 18 (eissn: 1746-6148, Copyright policy )
Authors: Evžen Korec; Lenka Ungrová; Jiří Hejnar; Adéla Grieblová;

doi: 10.21203/rs.3.rs-1293017/v1 , 10.1186/s12917-022-03290-9

pmid: 35590325

pmc: PMC9118790

Four novel genes associated with longevity found in Cane Corso purebred dogs

Abstract

Abstract Background: Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane Corso dogs with the aim to find genes that are associated with longevity. Results: SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs.Conclusions: Four SNPs associated with longevity in dogs were identified using GWAS. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane Corso dogs.

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Keywords

Longevity-associated genes, Veterinary medicine, Research, Longevity, Cane corso Italiano dog, Extending lifespan, Polymorphism, Single Nucleotide, Dogs, Longevity testing, SF600-1100, GWAS, Animals, Canes

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Top 10%
Average
Average
Green
gold