Cloning and Characterization of Two Cytoplasmic Dynein Intermediate Chain Genes in Mouse and Human
Copyright policy )Cloning and Characterization of Two Cytoplasmic Dynein Intermediate Chain Genes in Mouse and Human
Cytoplasmic dynein is a large multisubunit microtubule-based motor protein, which mediates movement of numerous intracellular organelles. We report here the identification of the human homologue of cytoplasmic dynein intermediate chain 1 gene (DNCI1) located on human chromosome 7q21.3-q22.1. The mouse orthologue (Dnci1) was identified along with another highly related gene, Dnci2, and their RNA in situ expression patterns were examined during mouse embryogenesis. Dnci1 was found to have a highly restricted expression domain in the developing forebrain as well as the peripheral nervous system (PNS), while Dnci2 displayed a broad expression profile throughout the entire central nervous system and most of the PNS. A dynamic expression profile was also found for Dnci2 in the developing mouse limb bud. The data presented here provide a framework for the further analysis of the functional role of Dnci1 and Dnci2 in mouse and DNCI1 in human.
- National Institute of Health Pakistan
- National Institutes of Health United States
- University of Hong Kong (香港大學) China (People's Republic of)
- National Institute of Diabetes and Digestive and Kidney Diseases United States
- University of Toronto Canada
Time Factors, 572, Limb Buds, Limb bud - metabolism, Molecular Sequence Data, Dynein atpase - genetics - metabolism - physiology, Embryonic and Fetal Development, Mice, Animals, Humans, Tissue Distribution, Amino Acid Sequence, Chromosomes, Artificial, Yeast, In Situ Hybridization, Base Sequence, Models, Genetic, Sequence Homology, Amino Acid, Reverse Transcriptase Polymerase Chain Reaction, Embryonic and fetal development, Dyneins, Blotting, Northern, Embryo, Mammalian, Tissue distribution, Sequence homology, Sequence homology, amino acid, amino acid
Time Factors, 572, Limb Buds, Limb bud - metabolism, Molecular Sequence Data, Dynein atpase - genetics - metabolism - physiology, Embryonic and Fetal Development, Mice, Animals, Humans, Tissue Distribution, Amino Acid Sequence, Chromosomes, Artificial, Yeast, In Situ Hybridization, Base Sequence, Models, Genetic, Sequence Homology, Amino Acid, Reverse Transcriptase Polymerase Chain Reaction, Embryonic and fetal development, Dyneins, Blotting, Northern, Embryo, Mammalian, Tissue distribution, Sequence homology, Sequence homology, amino acid, amino acid
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