Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels
Copyright policy )Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels
It is assumed that the combined effects of multiple common genetic variants explain a large part of variation of high‐density lipoprotein cholesterol (HDL‐C) plasma levels, but little evidence exists to corroborate this assumption. It was our objective to study the contribution of multiple common genetic variants of HDL‐C‐related genes to variation of HDL‐C plasma levels. A well‐characterized cohort of 546 Caucasian men with documented coronary artery disease was genotyped for common functional variants in genes that control reverse cholesterol transport: ATP‐binding cassette transporter A1, apolipoprotein A‐I and apolipoprotein‐E, cholesteryl ester transfer protein, hepatic lipase, lecithin : cholesterol‐acyl transferase, lipoprotein lipase, and scavenger receptor class B type 1. Multivariate linear regression showed that these variants, in conjunction, explain 12.4% (95% confidence interval: 6.9–17.9%) of variation in HDL‐C plasma levels. When the covariates smoking and body mass index were taken into account, the explained variation increased to 15.3% (9.4–21.2%), and when 10 two‐way interactions were incorporated, this percentage rose to 25.2% (18.9–31.5%). This study supports the hypothesis that multiple, mildly penetrant, but highly prevalent genetic variants explain part of the variation of HDL‐C plasma levels, albeit to a very modest extent. Multiple environmental and genetic influences on HDL‐C plasma levels still have to be elucidated.
- Maastricht University Netherlands
- University Medical Center Utrecht Netherlands
- Leiden University Medical Center Netherlands
- Utrecht University Netherlands
- Amsterdam UMC, location AMC Netherlands
Male, HDL, Scavenger Receptors, Genotype, Active, EMC COEUR-01-43-01, Biological Transport, Active, Coronary Artery Disease, Phosphatidylcholine-Sterol O-Acyltransferase, Cohort Studies, Apolipoproteins E, Models, Humans, Alleles, Glycoproteins, Apolipoprotein A-I, Cholesterol, HDL, Genetic Variation, Biological Transport, Lipase, Middle Aged, Biological, Cholesterol Ester Transfer Proteins, Lipoprotein Lipase, Cholesterol, ATP-Binding Cassette Transporters, Class B, Carrier Proteins, ATP Binding Cassette Transporter 1
Male, HDL, Scavenger Receptors, Genotype, Active, EMC COEUR-01-43-01, Biological Transport, Active, Coronary Artery Disease, Phosphatidylcholine-Sterol O-Acyltransferase, Cohort Studies, Apolipoproteins E, Models, Humans, Alleles, Glycoproteins, Apolipoprotein A-I, Cholesterol, HDL, Genetic Variation, Biological Transport, Lipase, Middle Aged, Biological, Cholesterol Ester Transfer Proteins, Lipoprotein Lipase, Cholesterol, ATP-Binding Cassette Transporters, Class B, Carrier Proteins, ATP Binding Cassette Transporter 1
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).42 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!