Distinctive role of central histamine H3 receptor in various orexigenic pathways
Copyright policy )Distinctive role of central histamine H3 receptor in various orexigenic pathways
Despite the well-established role of histamine as an anorexigenic neurotransmitter, the role of histamine H(3) receptors in feeding behavior is controversial. Herein we investigated the role of histamine H(3) receptor on several orexigenic agents in mice. Thioperamide (histamine H(3) receptor inverse agonist) inhibited neuropeptide Y- and nociceptin-induced hyperphagia but had no effect on U-50488 (opioid kappa-receptor agonist)-induced hyperphagia. In contrast, imetit (histamine H(3) receptor agonist) inhibited U-50488-induced hyperphagia but augmented neuropeptide Y-induced hyperphagia while it did not alter nociceptin-induced hyperphagia. These results indicate distinctive roles of histamine H(3) receptors in various orexigenic pathways.
Male, Nociceptin, 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Imidazoles, Thiourea, Appetite, Hyperphagia, Histamine Agonists, Mice, Inbred C57BL, Mice, Opioid Peptides, Piperidines, Animals, Receptors, Histamine H3, Neuropeptide Y, Histamine H3 Antagonists
Male, Nociceptin, 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Imidazoles, Thiourea, Appetite, Hyperphagia, Histamine Agonists, Mice, Inbred C57BL, Mice, Opioid Peptides, Piperidines, Animals, Receptors, Histamine H3, Neuropeptide Y, Histamine H3 Antagonists
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).12 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!