A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA
Copyright policy )A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA
LAP, a transcriptional activator, and LIP, a transcriptional repressor, are translated from a single mRNA species by using two AUGs within the same reading frame. These two proteins share the 145 C-terminal amino acids that contain the basic DNA-binding domain and the leucine zipper dimerization helix. Probably owing to its higher affinity for its DNA cognate sequences, LIP can attenuate the transcriptional stimulation by LAP in substoichiometric amounts. As revealed by transient transfection experiments, a moderate increase in the LAP/LIP ratio results in a significantly higher transcriptional activation of an appropriate target gene. The LAP/LIP ratio increases about 5-fold during terminal rat liver differentiation and is thus likely to modulate the activity of LAP in the intact animal.
- University of Geneva Switzerland
570, Leucine Zippers, Base Sequence, Transcription, Genetic, DNA Mutational Analysis, Molecular Sequence Data, Cell Differentiation, Rats, DNA-Binding Proteins, Repressor Proteins, Gene Expression Regulation, Genes, Liver, Protein Biosynthesis, CCAAT-Enhancer-Binding Proteins, Animals, RNA, Messenger, Ribosomes, Transcription Factors, ddc: ddc:570
570, Leucine Zippers, Base Sequence, Transcription, Genetic, DNA Mutational Analysis, Molecular Sequence Data, Cell Differentiation, Rats, DNA-Binding Proteins, Repressor Proteins, Gene Expression Regulation, Genes, Liver, Protein Biosynthesis, CCAAT-Enhancer-Binding Proteins, Animals, RNA, Messenger, Ribosomes, Transcription Factors, ddc: ddc:570
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).997 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!