Intracerebroventricular administration of NPY stimulates resistin gene expression in mice
Copyright policy )Intracerebroventricular administration of NPY stimulates resistin gene expression in mice
Resistin is thought to cause insulin resistance and link obesity to type 2 diabetes mellitus. However, little is known about the effects of neuropeptide Y (NPY) on resistin gene expression in white adipose tissue (WAT). Resistin gene expression was determined by northern blot analysis in food-deprived mice after NPY administration. Administered NPY (1 nmol/mouse) significantly increased resistin mRNA expression in WAT by 72% compared with artificial cerebrospinal fluid treated controls. These observations indicate that NPY might have a role in regulating resistin gene expression in WAT and that the novel brain-fat axis might be involved in the pathogenesis of obesity and related diseases.
- Kobe University Japan
Male, Microinjections, Proteins, Cerebral Ventricles, Mice, Adipose Tissue, Gene Expression Regulation, Hormones, Ectopic, Nerve Growth Factor, Animals, Intercellular Signaling Peptides and Proteins, Neuropeptide Y, Resistin, RNA, Messenger
Male, Microinjections, Proteins, Cerebral Ventricles, Mice, Adipose Tissue, Gene Expression Regulation, Hormones, Ectopic, Nerve Growth Factor, Animals, Intercellular Signaling Peptides and Proteins, Neuropeptide Y, Resistin, RNA, Messenger
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