Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy
Copyright policy )Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy
Key Points We evaluated interference with integrin alpha4–mediated stromal adhesion as a new acute lymphoblastic leukemia treatment. Integrin alpha4 blockade using natalizumab in combination with chemotherapy sensitizes pre-B acute lymphoblastic leukemia to chemotherapy.
- University of Washington United States
- University of California System United States
- University of California, Los Angeles United States
- University of Mary United States
- Sungkyunkwan University Korea (Republic of)
Mice, Knockout, Neoplasm, Residual, Integrases, Integrin alpha4, Natalizumab, Fusion Proteins, bcr-abl, Mice, SCID, Antibodies, Monoclonal, Humanized, Flow Cytometry, Real-Time Polymerase Chain Reaction, Mice, Bone Marrow, Drug Resistance, Neoplasm, Mice, Inbred NOD, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Cell Adhesion, Animals, Humans, RNA, Messenger, Child
Mice, Knockout, Neoplasm, Residual, Integrases, Integrin alpha4, Natalizumab, Fusion Proteins, bcr-abl, Mice, SCID, Antibodies, Monoclonal, Humanized, Flow Cytometry, Real-Time Polymerase Chain Reaction, Mice, Bone Marrow, Drug Resistance, Neoplasm, Mice, Inbred NOD, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Cell Adhesion, Animals, Humans, RNA, Messenger, Child
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