Characterization of the mouse JAB1 cDNA and protein
Copyright policy )Characterization of the mouse JAB1 cDNA and protein
JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex, the JAB1 signalosome in mammals and the COP9 complex in plants. The JAB1 signalosome is implicated in the phosphorylation of selected transcription factors, while the COP9 complex is involved in repression of photomorphogenesis in Arabidopsis. In this study, we describe the partial characterization of mouse JAB1 (mJAB1). The murine JAB1 protein is encoded by a gene located on mouse chromosome 1. mJAB1 mRNA is abundantly expressed in a variety of adult tissues as well as in mouse embryos. The JAB1 protein was readily detectable in many cell types and localized to both the nucleus and cytoplasm. Endogenous JAB1 protein is relatively stable and its degradation is not perturbed by blocking 26S proteasome activity, suggesting that this protein is not degraded by the ubiquitin-mediated proteolytic pathway.
- National Institute of Health Pakistan
- Biotechnology Institute United States
- The University of Texas Health Science Center at Houston United States
- The University of Texas Health Science Center at San Antonio United States
Cell Nucleus, Male, Cytoplasm, DNA, Complementary, COP9 Signalosome Complex, Hydrolysis, Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Chromosome Mapping, Fluorescent Antibody Technique, Gene Expression Regulation, Developmental, Embryo, Mammalian, Cell Line, DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Animals, Humans, Female
Cell Nucleus, Male, Cytoplasm, DNA, Complementary, COP9 Signalosome Complex, Hydrolysis, Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Chromosome Mapping, Fluorescent Antibody Technique, Gene Expression Regulation, Developmental, Embryo, Mammalian, Cell Line, DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Animals, Humans, Female
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