Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK)
Copyright policy )Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK)
The cancer-associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of it increased phosphorylation of focal adhesion kinase (FAK) and enhanced motility of SNU387 cells. Focal adhesion, kinase-related non-kinase (FRNK), an endogenous inhibitor of FAK, was significantly suppressed. This suggests that CAGE-promoted motility requires FAK. The inhibition of Rho-Associated coiled-coil-containing protein kinase (ROCK), an activator of FAK, also suppressed CAGE-promoted motility.
- Kangwon National University Korea (Republic of)
rho-Associated Kinases, Liver Neoplasms, Intracellular Signaling Peptides and Proteins, Protein Serine-Threonine Kinases, Transfection, DEAD-box RNA Helicases, Gene Expression Regulation, Neoplastic, Cell Movement, Focal Adhesion Kinase 1, Tumor Cells, Cultured, Humans, Neoplasm Invasiveness, Phosphorylation
rho-Associated Kinases, Liver Neoplasms, Intracellular Signaling Peptides and Proteins, Protein Serine-Threonine Kinases, Transfection, DEAD-box RNA Helicases, Gene Expression Regulation, Neoplastic, Cell Movement, Focal Adhesion Kinase 1, Tumor Cells, Cultured, Humans, Neoplasm Invasiveness, Phosphorylation
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