Interleukin Enhancer-binding Factor 3/NF110 Is a Target of YM155, a Suppressant of Survivin
Copyright policy )Interleukin Enhancer-binding Factor 3/NF110 Is a Target of YM155, a Suppressant of Survivin
Survivin is responsible for cancer progression and drug resistance in many types of cancer. YM155 selectively suppresses the expression of survivin and induces apoptosis in cancer cells in vitro and in vivo. However, the mechanism underlying these effects of YM155 is unknown. Here, we show that a transcription factor, interleukin enhancer-binding factor 3 (ILF3)/NF110, is a direct binding target of YM155. The enhanced survivin promoter activity by overexpression of ILF3/NF110 was attenuated by YM155 in a concentration-dependent manner, suggesting that ILF3/NF110 is the physiological target through which YM155 mediates survivin suppression. The results also show that the unique C-terminal region of ILF3/NF110 is important for promoting survivin expression and for high affinity binding to YM155.
- Astellas Pharma (Japan) Japan
Binding Sites, Dose-Response Relationship, Drug, Research, Survivin, Imidazoles, Antineoplastic Agents, Inhibitor of Apoptosis Proteins, Gene Expression Regulation, Neoplastic, Tandem Mass Spectrometry, Cell Line, Tumor, Gene Knockdown Techniques, Humans, Immunoprecipitation, RNA, Small Interfering, Nuclear Factor 90 Proteins, Promoter Regions, Genetic, Naphthoquinones, Protein Binding, Signal Transduction
Binding Sites, Dose-Response Relationship, Drug, Research, Survivin, Imidazoles, Antineoplastic Agents, Inhibitor of Apoptosis Proteins, Gene Expression Regulation, Neoplastic, Tandem Mass Spectrometry, Cell Line, Tumor, Gene Knockdown Techniques, Humans, Immunoprecipitation, RNA, Small Interfering, Nuclear Factor 90 Proteins, Promoter Regions, Genetic, Naphthoquinones, Protein Binding, Signal Transduction
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