<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>
Global Analysis of mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function

pmid: 17923096
Global Analysis of mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function
Although subcellular mRNA trafficking has been demonstrated as a mechanism to control protein distribution, it is generally believed that most protein localization occurs subsequent to translation. To address this point, we developed and employed a high-resolution fluorescent in situ hybridization procedure to comprehensively evaluate mRNA localization dynamics during early Drosophila embryogenesis. Surprisingly, of the 3370 genes analyzed, 71% of those expressed encode subcellularly localized mRNAs. Dozens of new and striking localization patterns were observed, implying an equivalent variety of localization mechanisms. Tight correlations between mRNA distribution and subsequent protein localization and function, indicate major roles for mRNA localization in nucleating localized cellular machineries. A searchable web resource documenting mRNA expression and localization dynamics has been established and will serve as an invaluable tool for dissecting localization mechanisms and for predicting gene functions and interactions.
- Max Planck Institute of Neurobiology Germany
- Max Planck Society Germany
- University of Toronto Canada
Cell Nucleus, Embryo, Nonmammalian, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, Gene Expression Regulation, Developmental, DEVBIO, Drosophila melanogaster, RNA, Animals, Drosophila Proteins, CELLBIO, RNA, Messenger, Databases, Nucleic Acid, Cell Division, In Situ Hybridization, Fluorescence
Cell Nucleus, Embryo, Nonmammalian, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, Gene Expression Regulation, Developmental, DEVBIO, Drosophila melanogaster, RNA, Animals, Drosophila Proteins, CELLBIO, RNA, Messenger, Databases, Nucleic Acid, Cell Division, In Situ Hybridization, Fluorescence
199 Research products, page 1 of 20
- 2017IsRelatedTo
- 2017IsRelatedTo
- 2017IsRelatedTo
- 2017IsRelatedTo
- 2017IsRelatedTo
- 2017IsRelatedTo
- 2017IsRelatedTo
- 2017IsRelatedTo
- 2017IsRelatedTo
- 2017IsRelatedTo
chevron_left - 1
- 2
- 3
- 4
- 5
chevron_right
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).874 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%