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Cell
Article
License: Elsevier Non-Commercial
Data sources: UnpayWall
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Cell
Article . 2007
License: Elsevier Non-Commercial
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Cell
Article . 2007 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
Cell
Article . 2008
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Global Analysis of mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function

Authors: Henry M. Krause; Neela Parthasarathy; Pavel Tomancak; Tanja Cerovina; Hideki Yoshida; Eric Lécuyer; Tomas Babak; +2 Authors

Global Analysis of mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function

Abstract

Although subcellular mRNA trafficking has been demonstrated as a mechanism to control protein distribution, it is generally believed that most protein localization occurs subsequent to translation. To address this point, we developed and employed a high-resolution fluorescent in situ hybridization procedure to comprehensively evaluate mRNA localization dynamics during early Drosophila embryogenesis. Surprisingly, of the 3370 genes analyzed, 71% of those expressed encode subcellularly localized mRNAs. Dozens of new and striking localization patterns were observed, implying an equivalent variety of localization mechanisms. Tight correlations between mRNA distribution and subsequent protein localization and function, indicate major roles for mRNA localization in nucleating localized cellular machineries. A searchable web resource documenting mRNA expression and localization dynamics has been established and will serve as an invaluable tool for dissecting localization mechanisms and for predicting gene functions and interactions.

Keywords

Cell Nucleus, Embryo, Nonmammalian, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, Gene Expression Regulation, Developmental, DEVBIO, Drosophila melanogaster, RNA, Animals, Drosophila Proteins, CELLBIO, RNA, Messenger, Databases, Nucleic Acid, Cell Division, In Situ Hybridization, Fluorescence

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    874
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 0.1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 0.1%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
874
Top 0.1%
Top 1%
Top 0.1%
hybrid