Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosis-related flora and vaginal cytokine responses in pregnant women
Copyright policy )Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosis-related flora and vaginal cytokine responses in pregnant women
The relationship between a single nucleotide polymorphism (TLR4 896 A > G) in the toll-like receptor-4 (TLR4) gene, qualitative and quantitative changes in vaginal micro-flora and vaginal interleukin (IL)-1beta and IL-1 receptor antagonist (IL-1ra) concentrations in pregnant women were evaluated.Qualitative and quantitative microbial methods were used to characterize vaginal micro-flora of 238 women at 18-22 weeks gestation. Polymerase chain reaction was used to determine TLR4 genotype. IL-1beta and IL-1ra concentrations in vaginal lavage samples were measured by ELISA.The TLR4 variant was identified in 10.3% of women. Carriage of this variant was associated with a median increase in vaginal pH (P = 0.05), a greater than 10-fold increase in vaginal Gardnerella vaginalis levels (P G polymorphism contributes to inter-individual differences in the vaginal immune defense against G. vaginalis and anaerobic Gram-negative rods.
- Cornell University United States
- Brigham and Women's Faulkner Hospital United States
- Harvard University United States
Adult, Guanine, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Adenine, Toll-Like Receptors, Receptors, Interleukin-1, Enzyme-Linked Immunosorbent Assay, Receptors, Cell Surface, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Toll-Like Receptor 4, Pregnancy, Vagina, Humans, Female, Pregnancy Trimesters, Pregnancy Complications, Infectious, Interleukin-1
Adult, Guanine, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Adenine, Toll-Like Receptors, Receptors, Interleukin-1, Enzyme-Linked Immunosorbent Assay, Receptors, Cell Surface, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Toll-Like Receptor 4, Pregnancy, Vagina, Humans, Female, Pregnancy Trimesters, Pregnancy Complications, Infectious, Interleukin-1
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).101 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!