Overexpression of the CXCL3 gene in response to oxidized low-density lipoprotein is associated with the presence of tendon xanthomas in familial hypercholesterolemia
Copyright policy )Overexpression of the CXCL3 gene in response to oxidized low-density lipoprotein is associated with the presence of tendon xanthomas in familial hypercholesterolemia
To examine if overexpression of certain chemokines and proinflammatory cytokines in response to oxidized low-density lipoprotein could be involved in the onset and development of tendon xanthomas (TX), we quantified IL-1β, TNF-α, and IL-8 and compared gene expression of PPAR-γ, NF-κBIA, IL-8, IL-1β, CXCL3, tryptase, and TNF-α in macrophages of familial hypercholesterolemia subjects with and without TX stimulated with oxidized low-density lipoprotein at 1, 3, 6, and 18 h of incubation. We propose that chemokines belonging to the CXC family could play an important role in the etiology of TX, with CXCL3 being a possible biological marker of onset and development of TX.
Adult, Male, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression, Middle Aged, Hyperlipoproteinemia Type II, Lipoproteins, LDL, Tendons, Xanthomatosis, Humans, Female, Connective Tissue Diseases, Chemokines, CXC
Adult, Male, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression, Middle Aged, Hyperlipoproteinemia Type II, Lipoproteins, LDL, Tendons, Xanthomatosis, Humans, Female, Connective Tissue Diseases, Chemokines, CXC
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