Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in Antibody Formation and Prophylactic Immunity in Mice Experimentally Infected with Toxoplasma gondii
Copyright policy )Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in Antibody Formation and Prophylactic Immunity in Mice Experimentally Infected with Toxoplasma gondii
AbstractProduction of antibodies against Toxoplasma gondii (T. gondii)‐derived stress proteins, T. gondii HSP70 (T.g.HSP70) and T.g.HSP30/bag1, in C57BL/6 and BALB/c mice perorally infected with cysts of the avirulent Fukaya strain of T. gondii was analyzed. Production of anti‐T.g.HSP70 IgG antibodies was transient, whereas production of anti‐T.g.HSP30/bag1 IgG antibodies persisted after infection in both C57BL/6 and BALB/c mice. C57BL/6 mice, a susceptible strain, predominantly produced IgG antibodies specific for T.g.HSP70, whereas BALB/c mice, a resistant strain, predominantly produced IgG antibodies specific for T.g.HSP30/bag1, after T. gondii infection. Immunization with rT.g.HSP30/bag1 enhanced, whereas immunization with rT.g.HSP70 reduced host protective immunity against T. gondii infection with a cyst‐forming avirulent strain, Fukaya, and a virulent strain, RH.
- Chiba University Japan
Protozoan Vaccines, Mice, Inbred BALB C, HSP30 Heat-Shock Proteins, Vaccination, H-2 Antigens, Protozoan Proteins, Antibodies, Protozoan, Membrane Proteins, Antigens, Protozoan, Mice, Inbred C57BL, Mice, Toxoplasmosis, Animal, Immunoglobulin G, Animals, Female, HSP70 Heat-Shock Proteins, Toxoplasma, Heat-Shock Proteins
Protozoan Vaccines, Mice, Inbred BALB C, HSP30 Heat-Shock Proteins, Vaccination, H-2 Antigens, Protozoan Proteins, Antibodies, Protozoan, Membrane Proteins, Antigens, Protozoan, Mice, Inbred C57BL, Mice, Toxoplasmosis, Animal, Immunoglobulin G, Animals, Female, HSP70 Heat-Shock Proteins, Toxoplasma, Heat-Shock Proteins
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