Cell cycle control of Wnt/β‐catenin signalling by conductin/axin2 through CDC20
Copyright policy )Cell cycle control of Wnt/β‐catenin signalling by conductin/axin2 through CDC20
Wnt/β‐catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/axil. We show that conductin levels peak at G2/M followed by a rapid decline during return to G1. In line with this, Wnt/β‐catenin target genes are low at G2/M and high at G1/S, and β‐catenin phosphorylation oscillates during the cell cycle in a conductin‐dependent manner. Conductin is degraded by the anaphase‐promoting complex/cyclosome cofactor CDC20. Knockdown of CDC20 blocks Wnt signalling through conductin. CDC20‐resistant conductin inhibits Wnt signalling and attenuates colony formation of colorectal cancer cells. We propose that CDC20‐mediated degradation of conductin regulates Wnt/β‐catenin signalling for maximal activity during G1/S.
- Universitätsklinikum Erlangen Germany
- University of Erlangen-Nuremberg Germany
Proteasome Endopeptidase Complex, Cdc20 Proteins, Protein Stability, Molecular Sequence Data, Mitosis, Cell Cycle Proteins, Cell Cycle Checkpoints, Protein Structure, Tertiary, Rats, Mice, Axin Protein, Cell Line, Tumor, Proteolysis, Animals, Humans, Amino Acid Sequence, Phosphorylation, Wnt Signaling Pathway, Conserved Sequence, Protein Binding
Proteasome Endopeptidase Complex, Cdc20 Proteins, Protein Stability, Molecular Sequence Data, Mitosis, Cell Cycle Proteins, Cell Cycle Checkpoints, Protein Structure, Tertiary, Rats, Mice, Axin Protein, Cell Line, Tumor, Proteolysis, Animals, Humans, Amino Acid Sequence, Phosphorylation, Wnt Signaling Pathway, Conserved Sequence, Protein Binding
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