Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
Copyright policy )Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable signal sequences target roughly a quarter of the human proteome to the ER. These short peptides, mostly located at the N-termini of proteins, are highly diverse. For most proteins targeted to the ER, it is the interactions between the signal sequences and the various ER targeting and translocation machineries such as the signal recognition particle (SRP), the protein-conducting channel Sec61, and the signal peptidase complex (SPC) that determine the proteins’ target location and provide translocation fidelity. In this review, we follow the signal peptide into the ER and discuss the recent insights that structural biology has provided on the governing principles of those interactions.
- Utrecht University Netherlands
- University Museum Utrecht Netherlands
Signal peptide, Proteome, Review, Protein targeting, Protein Sorting Signals, Endoplasmic Reticulum, Catalysis, ER translocon, Inorganic Chemistry, Chaperones, Endopeptidases, Humans, Physical and Theoretical Chemistry, Signal peptidase, Molecular Biology, Spectroscopy, Protein translocation, Organic Chemistry, Computer Science Applications, Protein Transport, Signal Recognition Particle, Endoplasmic reticulum, SEC Translocation Channels
Signal peptide, Proteome, Review, Protein targeting, Protein Sorting Signals, Endoplasmic Reticulum, Catalysis, ER translocon, Inorganic Chemistry, Chaperones, Endopeptidases, Humans, Physical and Theoretical Chemistry, Signal peptidase, Molecular Biology, Spectroscopy, Protein translocation, Organic Chemistry, Computer Science Applications, Protein Transport, Signal Recognition Particle, Endoplasmic reticulum, SEC Translocation Channels
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