Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives
Copyright policy )Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives
RFLPs at the low density lipoprotein receptor locus (LDLR) display marked linkage disequilibrium between each other. Cross-sectional analysis of a bi-alleleic ApaLI RFLP of LDLR showed that the 9.4- and 6.6-kb alleles were present in similar frequency between a group of 84 Caucasian essential hypertensive (HT) and a group of 96 normotensive subjects whose parents each had a similar blood pressure status at age > or = 50. After subdividing HTs into lean and obese, however, the frequency of the 6.6-kb allele in the 27 HTs with BMI > or = 26 kg/m2 was 0.63, compared with 0.39 for HTs with BMI < 26 (chi 2 = 8.8; P = 0.004). The difference in genotype frequencies was even more striking (chi 2 = 23; P = 0.00008), with a virtual absence of 9.4-kb homozygotes in the obese HT group (1 vs 22). Genetic variation at LDLR (19p13.2) is thus associated with obesity in HT.
- University of Sydney Australia
- Queensland University of Technology Australia
Male, Genotype, Homozygote, Chromosome Mapping, Genetic Variation, Blood Pressure, DNA, Middle Aged, Blotting, Southern, Gene Frequency, Receptors, LDL, Thinness, Hypertension, Humans, Female, Obesity, Deoxyribonucleases, Type II Site-Specific, Chromosomes, Human, Pair 19, Alleles, Polymorphism, Restriction Fragment Length
Male, Genotype, Homozygote, Chromosome Mapping, Genetic Variation, Blood Pressure, DNA, Middle Aged, Blotting, Southern, Gene Frequency, Receptors, LDL, Thinness, Hypertension, Humans, Female, Obesity, Deoxyribonucleases, Type II Site-Specific, Chromosomes, Human, Pair 19, Alleles, Polymorphism, Restriction Fragment Length
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