Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?
Copyright policy )Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?
The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of HLA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.
- University Hospital Brno Czech Republic
- Masaryk University Czech Republic
- Masaryk Memorial Cancer Institute Czech Republic
HLA-G Antigens, Brain Neoplasms, Macrophages, Histocompatibility Antigens Class I, Brain, Cell Communication, Immunity, Innate, Immunomodulation, Cell Movement, HLA Antigens, Humans, Gliosis, Microglia, Glioblastoma, HLA-E Antigens
HLA-G Antigens, Brain Neoplasms, Macrophages, Histocompatibility Antigens Class I, Brain, Cell Communication, Immunity, Innate, Immunomodulation, Cell Movement, HLA Antigens, Humans, Gliosis, Microglia, Glioblastoma, HLA-E Antigens
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