OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray
Copyright policy )OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray
Given its tumor-specific expression, including liver cancer, OY-TES-1 is a potential molecular marker for the diagnosis and immunotherapy of liver cancers. However, investigations of the mechanisms and the role of OY-TES-1 in liver cancer are rare. In the present study, based on a comprehensive bioinformatic analysis combined with RNA interference (RNAi) and oligonucleotide microarray, we report for the first time that downregulation of OY-TES-1 resulted in significant changes in expression of NANOG, CD9, CCND2 and CDCA3 in the liver cancer cell line BEL-7404. NANOG, CD9, CCND2 and CDCA3 may be involved in cell proliferation, migration, invasion and apoptosis, yet also may be functionally related to each other and OY-TES-1. Among these molecules, we identified that NANOG, containing a Kazal-2 binding motif and homeobox, may be the most likely candidate protein interacting with OY-TES-1 in liver cancer. Thus, the present study may provide important information for further investigation of the roles of OY-TES-1 in liver cancer.
- First Affiliated Hospital of Anhui Medical University China (People's Republic of)
- First Affiliated Hospital of Guangzhou Medical University China (People's Republic of)
- First Affiliated Hospital of Gannan Medical University China (People's Republic of)
- Guangxi Medical University
- Guangxi Medical University China (People's Republic of)
Homeodomain Proteins, Carcinoma, Hepatocellular, Amino Acid Motifs, Liver Neoplasms, Computational Biology, Apoptosis, Cell Cycle Proteins, Nanog Homeobox Protein, Neoplasm Proteins, Protein Structure, Tertiary, Gene Expression Regulation, Neoplastic, Cell Movement, Databases, Genetic, Protein Interaction Mapping, Cell Adhesion, Cyclin D2, Humans, Carrier Proteins, Cell Division, Oligonucleotide Array Sequence Analysis
Homeodomain Proteins, Carcinoma, Hepatocellular, Amino Acid Motifs, Liver Neoplasms, Computational Biology, Apoptosis, Cell Cycle Proteins, Nanog Homeobox Protein, Neoplasm Proteins, Protein Structure, Tertiary, Gene Expression Regulation, Neoplastic, Cell Movement, Databases, Genetic, Protein Interaction Mapping, Cell Adhesion, Cyclin D2, Humans, Carrier Proteins, Cell Division, Oligonucleotide Array Sequence Analysis
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