Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast
Copyright policy )Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast
We previously isolated a Saccharomyces cerevisiae mutant (HsTnII), which displays 40% reduced chronological lifespan as compared to the wild type (WT). In this study, we found HsTnII cultures to be characterized by fragmented and dysfunctional mitochondria, and by increased initiation of apoptosis during chronological aging as compared to WT. Expression of genes encoding subunits of mitochondrial electron transport chain and ATP synthase is significantly downregulated in HsTnII, and as a consequence, HsTnII is not able to respire ethanol. All these data confirm the importance of functional mitochondria and respiration in determining yeast chronological lifespan and apoptosis.
- University of Graz Austria
- KU Leuven Belgium
- Université Catholique de Louvain Belgium
- Katholieke Universiteit Leuven Belgium
- KATHOLIEKE UNIVERSITEIT LEUVEN Belgium
Mitochondrial morphology, Saccharomyces cerevisiae Proteins, Chronological lifespan, Respiration, Gene Expression, Microarray analysis, Apoptosis, Hydrogen Peroxide, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases, Mitochondria, DNA Transposable Elements, Mitochondrial function
Mitochondrial morphology, Saccharomyces cerevisiae Proteins, Chronological lifespan, Respiration, Gene Expression, Microarray analysis, Apoptosis, Hydrogen Peroxide, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases, Mitochondria, DNA Transposable Elements, Mitochondrial function
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