Characteristics of HIV-1 gp120 molecules that bind ancestor, intermediate and mature forms of VRC01-like antibodies
Copyright policy )Characteristics of HIV-1 gp120 molecules that bind ancestor, intermediate and mature forms of VRC01-like antibodies
Background A group of highly effective neutralizing antibodies, which target the site of CD4 binding on HIV-1 gp120, have recently been identified. These antibodies – called VRC01like antibodies – all originate from the same VH1-2*02 germline gene and, while the mature antibodies have undergone extensive maturation via non-homologous pathways, their recognition of the CD4-binding site of gp120 is similar. An efficacious vaccine that elicits VRC01-like antibodies will likely be required to bind to VH1-2*02-derived B cells to initiate their expansion and subsequent maturation, however, binding studies with reverted-ancestor VRC01-like antibodies and HIV-1 gp120 molecules typically show binding that is too weak to initiate B cell maturation.
Infectious Diseases, Virology, Poster Presentation, Immunologic diseases. Allergy, RC581-607
Infectious Diseases, Virology, Poster Presentation, Immunologic diseases. Allergy, RC581-607
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