High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions
Copyright policy )High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions
Mutations in transcription factor 4 (TCF4) have recently been described in myeloid dysplastic syndromes (MDS) and acute myeloid leukemia (AML). We analyzed the impact of TCF4 mRNA expression on clinical outcome in AML patients (n=525). Patients with high TCF4 expression (TCF4high, defined as the 25% highest TCF4 expressors) had a significantly worse overall survival (OS) and event-free survival (EFS) than patients with lower TCF4 expression (TCF4low) (5-year OS 18% vs. 44%, P<0.0001; 5-year EFS 15% vs. 34%, P<0.0001, respectively). This was confirmed in an independent cohort (n=436). Multivariate analysis showed that TCF4high is an independent prognostic factor for OS and EFS in the whole cohort and in patients carrying a normal karyotype.
- Radboud University Nijmegen Netherlands
Male, Real-Time Polymerase Chain Reaction, Cohort Studies, Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Diseases of the blood and blood-forming organs, RNA, Messenger, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Hematopoietic Stem Cell Transplantation, Middle Aged, Prognosis, Combined Modality Therapy, Survival Rate, Leukemia, Myeloid, Acute, Female, RC633-647.5, Follow-Up Studies
Male, Real-Time Polymerase Chain Reaction, Cohort Studies, Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Diseases of the blood and blood-forming organs, RNA, Messenger, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Hematopoietic Stem Cell Transplantation, Middle Aged, Prognosis, Combined Modality Therapy, Survival Rate, Leukemia, Myeloid, Acute, Female, RC633-647.5, Follow-Up Studies
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