MeCP2 Reinforces STAT3 Signaling and the Generation of Effector CD4 + T Cells by Promoting miR-124–Mediated Suppression of SOCS5
MeCP2 Reinforces STAT3 Signaling and the Generation of Effector CD4 + T Cells by Promoting miR-124–Mediated Suppression of SOCS5
A transcriptional regulator implicated in a neurodevelopmental disorder is required for the generation of certain effector T cells.
- Duke University United States
- Duke University Health System United States
- Duke Medical Center United States
- Duke University Hospital United States
- Third Military Medical University China (People's Republic of)
CD4-Positive T-Lymphocytes, Mice, Knockout, STAT3 Transcription Factor, Chromatin Immunoprecipitation, Methyl-CpG-Binding Protein 2, Blotting, Western, Histological Techniques, DNA Methylation, Diamines, Polymerase Chain Reaction, Mice, MicroRNAs, Gene Expression Regulation, Quinolines, Animals, Cytokines, Benzothiazoles, Organic Chemicals, Luciferases, Signal Transduction
CD4-Positive T-Lymphocytes, Mice, Knockout, STAT3 Transcription Factor, Chromatin Immunoprecipitation, Methyl-CpG-Binding Protein 2, Blotting, Western, Histological Techniques, DNA Methylation, Diamines, Polymerase Chain Reaction, Mice, MicroRNAs, Gene Expression Regulation, Quinolines, Animals, Cytokines, Benzothiazoles, Organic Chemicals, Luciferases, Signal Transduction
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