Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK
Copyright policy )Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK
Key Points Stimulation of the B-cell receptor of chronic lymphocytic leukemia cells results in activation of an unfolded protein response. Unfolded protein response activation following surface immunoglobulin M stimulation in vitro is dependent on the activity of BTK and SYK.
- University of Southampton United Kingdom
- University of Siena Italy
- University Hospital Southampton NHS Foundation Trust United Kingdom
- Southampton General Hospital United Kingdom
- Queen Mary University of London United Kingdom
Immunology, 610, Receptors, Antigen, B-Cell, Biochemistry, 630, Protein-Tyrosine Kinase, Receptors, Agammaglobulinaemia Tyrosine Kinase, Humans, Syk Kinase, Chronic, B-Lymphocytes, Leukemia, Medicine (all), B-Lymphocyte, B-Cell, Intracellular Signaling Peptides and Proteins, Hematology, Cell Biology, Protein-Tyrosine Kinases, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocytic, B-Lymphocytes; Humans; Immunoglobulin M; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Signal Transduction; Unfolded Protein Response; Hematology; Biochemistry; Cell Biology; Immunology; Medicine (all), Immunoglobulin M, Intracellular Signaling Peptides and Protein, Antigen, Unfolded Protein Response, Human, Signal Transduction
Immunology, 610, Receptors, Antigen, B-Cell, Biochemistry, 630, Protein-Tyrosine Kinase, Receptors, Agammaglobulinaemia Tyrosine Kinase, Humans, Syk Kinase, Chronic, B-Lymphocytes, Leukemia, Medicine (all), B-Lymphocyte, B-Cell, Intracellular Signaling Peptides and Proteins, Hematology, Cell Biology, Protein-Tyrosine Kinases, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocytic, B-Lymphocytes; Humans; Immunoglobulin M; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Signal Transduction; Unfolded Protein Response; Hematology; Biochemistry; Cell Biology; Immunology; Medicine (all), Immunoglobulin M, Intracellular Signaling Peptides and Protein, Antigen, Unfolded Protein Response, Human, Signal Transduction
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