Genetic Variations of Interleukin-23R (1143A>G) and BPI (A645G), but Not of NOD2, Are Associated with Acute Graft-versus-Host Disease after Allogeneic Transplantation
Copyright policy )Genetic Variations of Interleukin-23R (1143A>G) and BPI (A645G), but Not of NOD2, Are Associated with Acute Graft-versus-Host Disease after Allogeneic Transplantation
Single nucleotide polymorphisms (SNPs) in genes of the immune system predict for aGVHD and mortality after allo-SCT. We investigated the effect of SNPs in the NOD2, BPI, and IL-23R genes on posttransplantation outcome in a cohort of 304 patients. NOD2 patient and donor genotype and BPI recipient genotype were not associated with the occurrence of aGVHD. However, IL-23R-SNP in the donor was correlated with less aGVHD. This association could be confirmed in multivariate analysis (odds ratio [OR], 0.39; P = .039), which identified in vivo T cell depletion (OR, 0.32; P G) and BPI(A645G) SNPs appeared to be promising markers in this regard. The importance of these markers in prediction models for GVHD and relapse remain to be defined in large prospective clinical trials.
- TU Dresden Germany
- University Hospital Carl Gustav Carus Germany
Adult, Male, Bactericidal permeability-increasing protein, Adolescent, Genotype, Nod2 Signaling Adaptor Protein, Graft vs Host Disease, Polymorphism, Single Nucleotide, Disease-Free Survival, Cohort Studies, Gene Frequency, Humans, Transplantation, Homologous, CARD15, Child, Aged, Innate immunity, Transplantation, Hematopoietic Stem Cell Transplantation, Hematology, Receptors, Interleukin, Middle Aged, Immunity, Innate, Single nucleotide polymorphism, Acute Disease, Female, IL-23R
Adult, Male, Bactericidal permeability-increasing protein, Adolescent, Genotype, Nod2 Signaling Adaptor Protein, Graft vs Host Disease, Polymorphism, Single Nucleotide, Disease-Free Survival, Cohort Studies, Gene Frequency, Humans, Transplantation, Homologous, CARD15, Child, Aged, Innate immunity, Transplantation, Hematopoietic Stem Cell Transplantation, Hematology, Receptors, Interleukin, Middle Aged, Immunity, Innate, Single nucleotide polymorphism, Acute Disease, Female, IL-23R
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