Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation
Copyright policy )Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation
Significance This study used a genetic approach to probe the function of the F-actin nucleating Arp2/3 complex in skin development. Although the Arp2/3 complex was expected to be involved in morphogenesis and cell adhesion, loss of its activity did not result in architectural problems in the epidermis. However, Arp2/3 was essential for epidermal function. We revealed two unexpected functions for the Arp2/3 complex in the epidermis that are critical for tissue physiology: tight junction assembly/function and the regulation of YAP activity.
- Duke University United States
- Duke University Health System United States
- Duke Medical Center United States
- Duke University Hospital United States
Keratinocytes, Indoles, Cell Cycle Proteins, Diamines, Microarray Analysis, Phosphoproteins, Real-Time Polymerase Chain Reaction, Listeria monocytogenes, Actins, Mice, Actin-Related Protein 3, Multiprotein Complexes, Actin-Related Protein 2, Quinolines, Animals, Benzothiazoles, Epidermis, Organic Chemicals, Adaptor Proteins, Signal Transducing, Fluorescence Recovery After Photobleaching
Keratinocytes, Indoles, Cell Cycle Proteins, Diamines, Microarray Analysis, Phosphoproteins, Real-Time Polymerase Chain Reaction, Listeria monocytogenes, Actins, Mice, Actin-Related Protein 3, Multiprotein Complexes, Actin-Related Protein 2, Quinolines, Animals, Benzothiazoles, Epidermis, Organic Chemicals, Adaptor Proteins, Signal Transducing, Fluorescence Recovery After Photobleaching
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