mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy
Copyright policy )mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy
Significance N -myc downstream regulated gene 1 (NDRG1) is a central and druggable molecular hub integrating diverse therapy-induced microenvironmental factors to promote resistance toward alkylating chemotherapy. We suggest that NDRG1-mediated chemoprotection is achieved via binding and stabilizing methyltransferases, such as O 6 -methylguanine-DNA methyltransferase.
- Charité - University Medicine Berlin Germany
- University Hospital Heidelberg Germany
- University Hospital Frankfurt Germany
- University Hospital of Zurich Switzerland
- German Cancer Research Center Germany
1000 Multidisciplinary, DNA Repair, Brain Neoplasms, TOR Serine-Threonine Kinases, Immunoblotting, Lentivirus, Intracellular Signaling Peptides and Proteins, 500, Mice, Nude, 610 Medicine & health, Cell Cycle Proteins, Glioma, 10040 Clinic for Neurology, Gene Expression Regulation, Neoplastic, Mice, O(6)-Methylguanine-DNA Methyltransferase, Drug Resistance, Neoplasm, Animals, Humans, Glioblastoma, Hypoxia, Antineoplastic Agents, Alkylating, Neoplasm Transplantation, Plasmids
1000 Multidisciplinary, DNA Repair, Brain Neoplasms, TOR Serine-Threonine Kinases, Immunoblotting, Lentivirus, Intracellular Signaling Peptides and Proteins, 500, Mice, Nude, 610 Medicine & health, Cell Cycle Proteins, Glioma, 10040 Clinic for Neurology, Gene Expression Regulation, Neoplastic, Mice, O(6)-Methylguanine-DNA Methyltransferase, Drug Resistance, Neoplasm, Animals, Humans, Glioblastoma, Hypoxia, Antineoplastic Agents, Alkylating, Neoplasm Transplantation, Plasmids
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