Misaminoacylation and transamidation are required for protein biosynthesis in lactobacillus bulgaricus
Copyright policy )Misaminoacylation and transamidation are required for protein biosynthesis in lactobacillus bulgaricus
Aminoacylation studies with Lactobacillus bulgaricus show that this organism possesses glutamyl-tRNA synthetase activity; however, glutamyl-tRNA synthetase activity cannot be demonstrated. Instead, Glu-tRNAGln, which is formed by glutamyl-tRNA synthetase, is amidated by a specific amidotransferase to Gln-tRNAGln. The amide donor in this reaction is glutamine. Thus, Gln-tRNAGln in this organism is not formed by direct glutaminylation of tRNAGln, but instead by a pathway which involves misaminoacylation and transamidation.
- Yale University United States
- Nestlé (Switzerland) Switzerland
- Nestlé Netherlands
Amino Acyl-tRNA Synthetases, Glutamate-tRNA Ligase, Lactobacillus, Time Factors, Bacterial Proteins, Glutamates, Transferases, Glutamine, RNA, Transfer, Amino Acyl, Amides
Amino Acyl-tRNA Synthetases, Glutamate-tRNA Ligase, Lactobacillus, Time Factors, Bacterial Proteins, Glutamates, Transferases, Glutamine, RNA, Transfer, Amino Acyl, Amides
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