Artemin Is a Vascular-Derived Neurotropic Factor for Developing Sympathetic Neurons
Copyright policy )Artemin Is a Vascular-Derived Neurotropic Factor for Developing Sympathetic Neurons
Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRalpha3 receptor complex. Characterization of ARTN- and GFRalpha3-deficient mice revealed similar abnormalities in the migration and axonal projection pattern of the entire sympathetic nervous system. This resulted in abnormal innervation of target tissues and consequent cell death due to deficiencies of target-derived neurotrophic support. ARTN is expressed along blood vessels and in cells nearby to sympathetic axonal projections. In the developing vasculature, ARTN is expressed in smooth muscle cells of the vessels, and it acts as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues. The chemoattractive properties of ARTN were confirmed by the demonstration that sympathetic neuroblasts migrate and project axons toward ARTN-soaked beads implanted into mouse embryos.
- Washington University in St. Louis United States
- University of Mary United States
Mice, Knockout, Ganglia, Sympathetic, Glial Cell Line-Derived Neurotrophic Factor Receptors, Horner Syndrome, Membrane Glycoproteins, Cell Death, Cell Survival, Neuroscience(all), Chemotaxis, Gene Expression Regulation, Developmental, Cell Differentiation, Nerve Tissue Proteins, Muscle, Smooth, Vascular, Mice, Fetus, Cell Movement, Animals, Blood Vessels, Female, Nerve Growth Factors, Digestive System
Mice, Knockout, Ganglia, Sympathetic, Glial Cell Line-Derived Neurotrophic Factor Receptors, Horner Syndrome, Membrane Glycoproteins, Cell Death, Cell Survival, Neuroscience(all), Chemotaxis, Gene Expression Regulation, Developmental, Cell Differentiation, Nerve Tissue Proteins, Muscle, Smooth, Vascular, Mice, Fetus, Cell Movement, Animals, Blood Vessels, Female, Nerve Growth Factors, Digestive System
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).279 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!