Association of apolipoprotein A5 gene polymorphisms and serum lipid levels

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2011 English Publisher:Elsevier BVJournal:Nutrition, Metabolism and Cardiovascular Diseases, volume 21, pages 947-956 (issn: 0939-4753,

Authors: Y-Y, Li; R-X, Yin; C-Q, Lai; M, Li; X-J, Long; K-L, Li; W-Y, Liu; +2 Authors

doi: 10.1016/j.numecd.2010.04.004

pmid: 20708914

Association of apolipoprotein A5 gene polymorphisms and serum lipid levels

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Abstract

Apolipoprotein (APO) A5 gene polymorphisms have been associated with increased plasma triglyceride (TG), but the results are inconsistent. The present study was undertaken to detect the APOA5 gene polymorphisms and their associations with lipid profiles in the Guangxi Hei Yi Zhuang and Han populations.Genotyping of the APOA5 -1131T>C, c.553G>T and c.457G>A was performed in 490 subjects of Hei Yi Zhuang and 540 participants of Han Chinese aged 15-89 years. The -1131C allele frequency was higher in high total cholesterol (TC) than in normal TC subgroups in both the ethnic groups (PC genotype or allele, and the levels of TG were associated with c.553G>T genotype (PA genotype or allele, and the levels of TC were associated with -1131T>C allele (P<0.05).The differences in the lipid profiles between the two ethnic groups might partly result from different APOA5 gene-environmental interactions.

Related Organizations

Tufts University
United States
Guangxi Medical University
China (People's Republic of)

Keywords

Adult, Aged, 80 and over, Hypertriglyceridemia, Male, China, Adolescent, Hypercholesterolemia, Coronary Artery Disease, Middle Aged, Lipids, Linkage Disequilibrium, Gene Frequency, Apolipoprotein A-V, Leukocytes, Humans, Female, Alleles, Apolipoproteins A, Genetic Association Studies, Aged

13 Research products, page 1 of 2

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