Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: V. Association of CYP1A2 1545 C>T polymorphism
Copyright policy )Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: V. Association of CYP1A2 1545 C>T polymorphism
Tardive dyskinesia (TD) is an iatrogenic disorder observed in approximately 20-30% of schizophrenia patients on long-term treatment with typical antipsychotic drugs. CYP1A2 is involved in the metabolism of atypical antipsychotic drugs such as clozapine and olanzapine. It is not directly involved in the metabolism of typical antipsychotic drugs, but gains importance when the schizophrenia patients are under long-term chronic treatment, acting as a low-affinity high-capacity metabolizing enzyme. In this study, we have completely sequenced the coding region to ascertain the presence of common coding polymorphisms and their role if any in susceptibility to TD and schizophrenia. Four previously reported polymorphisms, CYP1A2*1F (intron A), rs2472304 & rs3743484 (intron D) and rs2470890 (CYP1A2 1545 C>T) in exon 7 were identified. We further investigated whether the CYP1A2 1545 C>T polymorphism has any role to play in susceptibility to TD and in schizophrenia per se. Association of this single nucleotide polymorphism with TD (P=0.03) and schizophrenia (P=0.04) was observed, but was rendered insignificant after corrections for multiple comparisons.
- University of Pittsburgh United States
- University of Delhi India
Dyskinesia, Drug-Induced, DNA Mutational Analysis, Exons, Polymorphism, Single Nucleotide, Risk Assessment, Introns, Cross-Sectional Studies, Treatment Outcome, Gene Frequency, Haplotypes, Cytochrome P-450 CYP1A2, Risk Factors, Case-Control Studies, Chronic Disease, Odds Ratio, Schizophrenia, Humans, Genetic Predisposition to Disease, Antipsychotic Agents, Retrospective Studies
Dyskinesia, Drug-Induced, DNA Mutational Analysis, Exons, Polymorphism, Single Nucleotide, Risk Assessment, Introns, Cross-Sectional Studies, Treatment Outcome, Gene Frequency, Haplotypes, Cytochrome P-450 CYP1A2, Risk Factors, Case-Control Studies, Chronic Disease, Odds Ratio, Schizophrenia, Humans, Genetic Predisposition to Disease, Antipsychotic Agents, Retrospective Studies
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).30 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!