Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse.
Copyright policy )Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse.
Recently, it has been reported that Na,K-ATPase in the renal epithelia of human autosomal dominant polycystic kidney disease and cpk mouse, a murine model of autosomal recessive polycystic kidney disease, mislocates to apical plasma membrane and that mislocated Na,K-ATPase causes the cyst formation. Whether the DBA/2FG-pcy mice, which are presumably a suitable model for autosomal dominant polycystic kidney disease, also exhibit the reversal polarity of Na,K-ATPase localization was examined. Kidneys of newborn DBA/2FG-pcy mice, and those at early and late stages of cyst development were examined by immunohistochemical techniques. At any stage, abnormal distribution of Na,K-ATPase on the apical membranes of tubular epithelial cells could not be detected. It is suggested that cysts can be formed without reversed polarity of Na,K-ATPase distribution in pcy mice.
- Kansai Medical University Japan
- Fujita Health University Japan
Silver Staining, Blotting, Western, Kidney, Polycystic Kidney, Autosomal Dominant, Immunohistochemistry, Epithelium, Mice, Mutant Strains, Immunoenzyme Techniques, Disease Models, Animal, Mice, Animals, Newborn, Mice, Inbred DBA, Disease Progression, Animals, Humans, Sodium-Potassium-Exchanging ATPase
Silver Staining, Blotting, Western, Kidney, Polycystic Kidney, Autosomal Dominant, Immunohistochemistry, Epithelium, Mice, Mutant Strains, Immunoenzyme Techniques, Disease Models, Animal, Mice, Animals, Newborn, Mice, Inbred DBA, Disease Progression, Animals, Humans, Sodium-Potassium-Exchanging ATPase
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