Osteopetrosis-Associated Transmembrane Protein 1 Recruits RNA Exosome To Restrict Hepatitis B Virus Replication
Copyright policy )Osteopetrosis-Associated Transmembrane Protein 1 Recruits RNA Exosome To Restrict Hepatitis B Virus Replication
Hepatitis B virus (HBV) is a human pathogen infecting the liver to cause a variety of diseases ranging from acute hepatitis to advanced liver diseases, fulminate hepatitis, liver cirrhosis, and hepatocellular carcinoma, thereby causing a major health problem worldwide. In this study, we demonstrated that Ostm1 plays an inhibitory role in HBV protein production, RNA expression, and DNA replication. However, Ostm1 has no effect on the activities of the four HBV promoters; instead, it binds to HBV RNA and recruits RNA exosomes to promote HBV RNA degradation. We further demonstrated that the anti-HBV activity of Ostm1 is independent of the interferon signaling pathway. In conclusion, this study reveals a distinct mechanism underlying the repression of HBV replication and suggests that Ostm1 is a potential therapeutic agent for HBV infection.
- Wuhan University China (People's Republic of)
- Jinan University China (People's Republic of)
- State Key Laboratory of Virology China (People's Republic of)
- University of Jinan China (People's Republic of)
Hepatitis B virus, Hepatitis B Surface Antigens, Exosome Multienzyme Ribonuclease Complex, Ubiquitin-Protein Ligases, Interferon-alpha, Membrane Proteins, RNA-Binding Proteins, Hep G2 Cells, Exosomes, Virus Replication, Interferon-gamma, HEK293 Cells, Protein Domains, Gene Knockdown Techniques, Humans, RNA, Viral, Hepatitis B e Antigens, HeLa Cells
Hepatitis B virus, Hepatitis B Surface Antigens, Exosome Multienzyme Ribonuclease Complex, Ubiquitin-Protein Ligases, Interferon-alpha, Membrane Proteins, RNA-Binding Proteins, Hep G2 Cells, Exosomes, Virus Replication, Interferon-gamma, HEK293 Cells, Protein Domains, Gene Knockdown Techniques, Humans, RNA, Viral, Hepatitis B e Antigens, HeLa Cells
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