Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases?
Copyright policy )Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases?
Abstract Using the patch clamp whole-cell recording technique, we studied expression of K+ channels in mAb-defined T cell subsets from diseased C3H-lpr/lpr and C3H-gld/gld mice and from healthy C3H-HeJ congenic controls. Both mutant mouse strains develop a lupus-like syndrome accompanied by hyperplasia of a functionally and phenotypically abnormal T cell subset. These defective cells, which are Thy-1.2+ CD4- CD8- B220+ F23.1+, display an abundance of type l K+ channels. Phenotypically similar lymph node T cells from normal C3H-HeJ mice, or young C3H-lpr/lpr mice before the onset of disease, do not display large numbers of type l K+ channels. CD4+ CD8- T cells (helper/inducer) from the mutant mice express a small number of type n K+ channels, and CD4- CD8+ T cells (suppressor/cytotoxic) show a low level of type l or n' K+ channels, as do their phenotypically equivalent counterparts in the normal mouse thymus. These results suggest that the abundant expression of type l K+ channels is a marker for the defective lpr and gld T cell subset and may reflect the "abnormal" proliferative status of these cells.
- University of California, Irvine United States
Antigens, Differentiation, T-Lymphocyte, Mice, Inbred C3H, Staining and Labeling, T-Lymphocytes, Phycoerythrin, Ion Channels, Lymphoproliferative Disorders, Electrophysiology, Mice, Phenotype, Species Specificity, Antigens, Surface, Mutation, Potassium, Animals, Thy-1 Antigens, Lymph Nodes
Antigens, Differentiation, T-Lymphocyte, Mice, Inbred C3H, Staining and Labeling, T-Lymphocytes, Phycoerythrin, Ion Channels, Lymphoproliferative Disorders, Electrophysiology, Mice, Phenotype, Species Specificity, Antigens, Surface, Mutation, Potassium, Animals, Thy-1 Antigens, Lymph Nodes
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