Association of human cathelicidin (hCAP-18/LL-37) gene expression with cardiovascular disease risk factors
Copyright policy )Association of human cathelicidin (hCAP-18/LL-37) gene expression with cardiovascular disease risk factors
Antimicrobial peptides (AMPs) are components of the innate immune system. In addition, evidence suggests that these peptides are associated with various inflammatory diseases. We examined whether expression of the cathelicidin LL-37 in peripheral blood mononuclear cells (PBMCs) is associated with cardiovascular risk factors.A total of 90 men and 87 women selected from STANISLAS cohort were studied. Expression of LL-37 mRNA isolated from PBMCs of these subjects was quantified by quantitative RT-PCR. Anthropometric measurements and biochemical profiles were assessed for each individual. In women, LL-37 mRNA expression was significantly and positively correlated with body mass index (BMI) (p
- UNIVERSITE DE NANCY II France
Adult, Blood Glucose, Male, Metabolic Syndrome, Anthropometry, Lipoproteins, Gene Expression, Blood Pressure, Middle Aged, Lipids, Blood Cell Count, Sex Chromatin, Cardiovascular Diseases, Cathelicidins, Risk Factors, Leukocytes, Mononuclear, Humans, Female, Aged, Antimicrobial Cationic Peptides
Adult, Blood Glucose, Male, Metabolic Syndrome, Anthropometry, Lipoproteins, Gene Expression, Blood Pressure, Middle Aged, Lipids, Blood Cell Count, Sex Chromatin, Cardiovascular Diseases, Cathelicidins, Risk Factors, Leukocytes, Mononuclear, Humans, Female, Aged, Antimicrobial Cationic Peptides
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