Genetic variation of an acid phosphatase (Acp-2) in the laboratory rat: Possible homology with mouse AP-1 and human ACP2
Copyright policy )Genetic variation of an acid phosphatase (Acp-2) in the laboratory rat: Possible homology with mouse AP-1 and human ACP2
A genetic locus controlling the electrophoretic mobility of an acid phosphatase in the rat (Rattus norvegicus) is described. The locus, designed Acp-2, is not expressed in erythrocytes but is expressed in all other tissues studied. The product of Acp-2 hydrolyzes a wide variety of phosphate monoesters and is inhibited by L(+)-tartaric acid. Inbred rat strains have fixed either allele Acp-2a or allele Acp-2b. Codominant expression is observed in the respective F1 hybrids. Backcross progenies revealed the expected 1:1 segregation ratio. Possible loose linkage was found between the Acp-2 and the Pep-3 gene loci at a recombination frequency of 0.36 +/- 0.06.
- University of Göttingen Germany
- University of Freiburg Germany
- Business Breakthrough University Japan
- University of Pretoria South Africa
Isoenzymes, Mice, Genetic Linkage, Acid Phosphatase, Animals, Genetic Variation, Humans, Tissue Distribution, Alleles, Rats
Isoenzymes, Mice, Genetic Linkage, Acid Phosphatase, Animals, Genetic Variation, Humans, Tissue Distribution, Alleles, Rats
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