Association of VNTR polymorphisms inDRD4, 5-HTTandDAT1genes with obesity
Copyright policy )Association of VNTR polymorphisms inDRD4, 5-HTTandDAT1genes with obesity
To investigate the association between VNTR polymorphisms of DRD4, DAT1 and 5-HTT genes and obesity.Peripheral blood samples of 234 obese (BMI ≥ 30) and 148 healthy individuals (BMI ≤ 25) were objected to PCR to detect the VNTR of the 2nd intron of 5-HTT, 3rd exon of DRD4 and 3'UTR of DAT1 genes.The association between obesity and genotype distributions of 5-HTT, DAT1 and DRD4 genes and between obesity and distributions of allele frequencies were tested by Chi Square (χ(2)) test and were not found statistically significant. BMI values for genotype of obese and morbidly obese (BMI > 40) individuals were analyzed by Kruskal-Wallis and not found statistically significant differences between BMI values for the most frequent genotypes of 5-HTT, DAT1 and DRD4 genes.As a conclusion, there was no association between 5-HTT, DAT1 and DRD4 genes VNTR polymorphisms and obesity.
- Hacettepe University Turkey
Male, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Polymorphism, Genetic, Genotype, Receptors, Dopamine D4, Minisatellite Repeats, Body Mass Index, Gene Frequency, Case-Control Studies, Humans, Female, Obesity
Male, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Polymorphism, Genetic, Genotype, Receptors, Dopamine D4, Minisatellite Repeats, Body Mass Index, Gene Frequency, Case-Control Studies, Humans, Female, Obesity
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