Interaction of smoothened with integrin‐linked kinase in primary cilia mediates Hedgehog signalling
Copyright policy )Interaction of smoothened with integrin‐linked kinase in primary cilia mediates Hedgehog signalling
Here we report that ILK localizes in the mouse primary cilium, a sensory organelle required for signalling by the Hedgehog (Hh) pathway. Genetic or pharmacological inhibition of ILK blocks ciliary accumulation of the Hh pathway effector smoothened (Smo) and suppresses the induction of Gli transcription factor mRNAs by SHh. Conditional deletion of ILK or Smo also inhibits SHh‐driven activation of Gli2 in the embryonic mouse cerebellum. ILK regulation of Hh signalling probably requires the physical interaction of ILK and Smo in the cilium, and we also show selective cilia‐associated interaction of ILK with β‐arrestin, a known mediator of Smo‐dependent signalling.
- National Cancer Institute United States
- University of British Columbia Canada
- Monash University Australia
- Hudson Institute of Medical Research Australia
- University of Adelaide Australia
Arrestins, Messenger, Kruppel-Like Transcription Factors, Protein Serine-Threonine Kinases, Zinc Finger Protein Gli2, Cell Line, Receptors, G-Protein-Coupled, G-Protein-Coupled, Mice, Cerebellum, Receptors, Animals, Hedgehog Proteins, Cilia, RNA, Messenger, Protein Kinase Inhibitors, integrin-linked kinase, Protein-Serine-Threonine Kinases, Smoothened Receptor, cerebellar development, Hedgehog signalling, RNA, primary cilium, Signal Transduction
Arrestins, Messenger, Kruppel-Like Transcription Factors, Protein Serine-Threonine Kinases, Zinc Finger Protein Gli2, Cell Line, Receptors, G-Protein-Coupled, G-Protein-Coupled, Mice, Cerebellum, Receptors, Animals, Hedgehog Proteins, Cilia, RNA, Messenger, Protein Kinase Inhibitors, integrin-linked kinase, Protein-Serine-Threonine Kinases, Smoothened Receptor, cerebellar development, Hedgehog signalling, RNA, primary cilium, Signal Transduction
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